Standing the Test of Time

Like our namesake, the Parthenon, Hox+ proteins resist degradation and persist through time.  Furthermore, the Parthenon heritage is an omage to our parent company, Ship of Theseus, which is developing specific Hox-based drug candidates.

​Invention

The point mutations in Hox+ were identified by Dr. Pengbo Zhou at Weill Cornell University.  Dr. Zhou's team discovered that all 39 of the Hox genes are ubiquinated via Cullin4a (Cul4a).  The team then identified a minimal set of point mutations in the ubiquinated region and confirmed in vitro and in vivo that proteins with such point mutations (aka "LEXE") exhibit drastically extended intracellular half-life.

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Manufacturing

All Parthenon Bioreagent proteins are manufactured in the laboratory of Ichor Life Sciences of Syracuse New York.  Ichor Life Science specializes in advanced proteins such as the Hox family, which are intrinsically disordered.  Release criteria include >90% purity by SDS gel electrophoresis.  Proteins are manufactured in e.coli or mammalian systems depending on the Hox protein of choice.