HoxA5+ Degradation-Resistant Cell-Penetrating Protein (50 ug)
HoxA5 overexpression has been shown to slow motility of various epithelial cancers.
HoxA5 overexpression in adipocytes also leads to fat browning through the formation of additional mitochondria, and such over-expression has led to weight loss in mice.
HoxA5+ protein has been shown to be superior to equivalent dosages in ability to prevent A549 lung cancer line motility in vitro.
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HOXA5 correlates inversely with prognosis in human cancers
•Loss of HOXA5 correlates with worse liver [1], gastric [2], and colon [3] cancer prognosis
•Lung cancer cell in vitro invasiveness correlates inversely with HOXA5 [4]
HOXA5 knock-in triggers cancer line apoptosis and reduces invasiveness
•HOXA5 knock-down in liver cancer cell line boosts tumor growth when implanted [1]
•HOXA5 overexpression in gastric cancer cell lines decreases proliferation in vitro [2]
•HOXA5 knock-in in lung cancer cell lines decreases tumor growth when implanted, and knock-in (or down) decreases (or increases) in Boyden Chamber invasiveness [4]
•Mice overexpressing HOXA5 in endothelial cells slow growth of implanted mammary tumors (but have mildly stunted ability to heal wounds) via lower VEGF and TSP-2 [5]
•HOXA5 knock-in in cervical cancer lines inhibits proliferation and causes apoptosis [6]
•HOXA5 overexpression in hemangioma cell lines halts tumor growth in vivo when implanted via TSP-2 and HIFa [7], and for colon cancer via Wnt [3]
•However, HOXA5 knock-down limited growth of implanted melanoma cells [8]